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Thus, c-Met and its associated signaling pathways are clinically important therapeutic targets. However, in cancer cells, aberrant HGF/c-Met axis activation, which is closely related to c-Met gene mutations, overexpression, and amplification, promotes tumor development and progression by stimulating the PI3K/AKT, Ras/MAPK, JAK/STAT, SRC, Wnt/β-catenin, and other signaling pathways.
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The binding of HGF to c-Met initiates a series of intracellular signals that mediate embryogenesis and wound healing in normal cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. Fan of other Ubisoft games? Check out this wiki page to visit their subreddits.C-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. A network of Assassin's Creed extended fan community, featuring art, wikis, YouTube channels, notable fan Twitters, and more! Late to the franchise and want a quick catch-up? Check out the story summaries on our wiki. Check out Frequently Asked Questions first. Have a question? It's probably been answered before. Looking for some tips and tricks about the various Assassin's Creed games? Then this page is for you. Having technical issues with AC Valhalla? Check our tech support megathread.ĪC Valhalla Tech Support Tutorials and Guides
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Full Subreddit Rules AC Valhalla Tech Support Visit our FAQ and search for older posts on the subject before asking non-discussion questions. Posts asking questions such as "what order should I play the games in?", "what do I need to play to get the full story?", "is Assassin's Creed X, dlc, or season pass worth it?" etc. 5 // Frequently Asked Questionsĭo not post questions that can be easily looked up. Use where necessary, but do not spoil anything in the title itself. Posts with short, misleading, incorrect or clickbait titles (including 'DAE' / 'Am I the only one") will be removed. The subject of your post must be included in the title. Insulting/hateful speech based on race, gender, sexual orientation and religion will not be tolerated and will result in a ban. Result: Valhalla Spoiler 3 // Disrespectful Behaviorĭisrespectful posts and comments will be removed. Result: Spoiler goes here (#s "Eivor is a Viking.")
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How to tag spoilers: >!Spoiler goes here!< Use the following formatting instructions to tag text/comments: Include in your title, but do not spoil anything in the title itself. 2 // Spoiler PolicyĬurrent spoiler policy covers all Valhalla Year 2 content, including:Īny recently released comics, novels or other transmedia NSFW and pirated/illegal content will be removed, and risk a ban. Posts about topics covered within the last week will be removed. that do not contribute to meaningful discussion will be removed at the mods' discretion. Low-effort submissions, such as memes, screenshots, game clips, etc. Follow us on Twitter! Assassin's Creed Discord Server RULES 1 // Submission GuidelinesĪll submissions must be in English and directly related to the Assassin’s Creed series. Subreddit for news, discussion and more about Ubisoft's Assassin's Creed franchise.